Organocatalytic synthesis of drugs and bioactive natural products

被引：365

作者：

de Figueiredo, Renata Marcia ^{[1
]}

Christmann, Mathias ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 2007卷 / 16期

关键词：

total synthesis; natural products; organocatalysis; medicinal chemistry; asymmetric synthesis;

D O I：

10.1002/ejoc.200700032

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalytic reactions are a key element in the design of sustainable chemical processes. As witnessed in the field of transition metal-catalysed processes, only those reactions that are reliable over a broad substrate range and tolerant toward a multitude of functional groups have found their way into the repertoire of preparative chemists. Natural product synthesis provides a good benchmark for the maturity of a new synthetic method and in this microreview we discuss the scope and limitations of organocatalytic reactions in the synthesis of biologically important molecules. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007).

引用

页码：2575 / 2600

页数：26

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